| First Author | Sakurai N | Year | 2011 |
| Journal | J Clin Invest | Volume | 121 |
| Issue | 7 | Pages | 2583-98 |
| PubMed ID | 21646720 | Mgi Jnum | J:175657 |
| Mgi Id | MGI:5286812 | Doi | 10.1172/JCI45682 |
| Citation | Sakurai N, et al. (2011) The LRF transcription factor regulates mature B cell development and the germinal center response in mice. J Clin Invest 121(7):2583-98 |
| abstractText | B cells play a central role in immune system function. Deregulation of normal B cell maturation can lead to the development of autoimmune syndromes as well as B cell malignancies. Elucidation of the molecular features of normal B cell development is important for the development of new target therapies for autoimmune diseases and B cell malignancies. Employing B cell-specific conditional knockout mice, we have demonstrated here that the transcription factor leukemia/lymphoma-related factor (LRF) forms an obligate dimer in B cells and regulates mature B cell lineage fate and humoral immune responses via distinctive mechanisms. Moreover, LRF inactivation in transformed B cells attenuated their growth rate. These studies identify what we believe to be a new key factor for mature B cell development and provide a rationale for targeting LRF dimers for the treatment of autoimmune diseases and B cell malignancies. |
