| First Author | Inoue J | Year | 2017 |
| Journal | Biosci Biotechnol Biochem | Volume | 81 |
| Issue | 5 | Pages | 922-930 |
| PubMed ID | 28067590 | Mgi Jnum | J:271859 |
| Mgi Id | MGI:6282235 | Doi | 10.1080/09168451.2016.1274642 |
| Citation | Inoue J, et al. (2017) BCL11B gene heterozygosity causes weight loss accompanied by increased energy consumption, but not defective adipogenesis, in mice. Biosci Biotechnol Biochem 81(5):922-930 |
| abstractText | BCL11B is a zinc finger-type transcription factor that regulates the development of the white adipose tissue (WAT), skin, central nervous system, and immune system. BCL11B is required for proper adipocyte differentiation, and BCL11B-/- embryos at E19.5 have very low amounts of the subcutaneous WAT. Here, we demonstrated that BCL11B+/- mice have lower body weight than BCL11B+/+ mice, whereas the expression of adipogenic marker genes in the WAT was comparable between BCL11B+/+ and BCL11B+/- mice. Histological analysis indicated that BCL11B+/- mice fed a high-fat diet have much smaller white adipocytes and lipid droplets in the WAT and liver, respectively. In addition, BCL11B+/- mice had increased energy consumption under both standard and high-fat diets. Thus, this study identifies BCL11B as a regulator of energy metabolism, and it is unlikely that BCL11B functions in the WAT contribute to energy metabolism in BCL11B+/- mice. |
