| First Author | Go R | Year | 2012 |
| Journal | Leuk Res | Volume | 36 |
| Issue | 8 | Pages | 1035-40 |
| PubMed ID | 22640496 | Mgi Jnum | J:320788 |
| Mgi Id | MGI:6870663 | Doi | 10.1016/j.leukres.2012.04.028 |
| Citation | Go R, et al. (2012) Impairment in differentiation and cell cycle of thymocytes by loss of a Bcl11b tumor suppressor allele that contributes to leukemogenesis. Leuk Res 36(8):1035-40 |
| abstractText | Genetic changes in T-ALL are classified into type A abnormalities leading to arrest at a specific stage of T-cell differentiation and type B abnormalities that target cellular processes including cell cycle regulation. Mutations and deletion of a BCL11B haploinsuffiecient tumor suppressor allele have been found in 10-16% of T-ALL subgroups. Analysis of Bcl11b(KO/+) mice revealed impaired T-cell differentiation at two different stages and attenuation of gamma-ray induced cell-cycle arrest at S/G2/M phase in immature CD8 single positive cells. Hence, those phenotypes provided by loss of a Bcl11b allele favor that Bcl11b mutation belongs to type B abnormalities. |
