| First Author | Waterfield M | Year | 2014 |
| Journal | Nat Immunol | Volume | 15 |
| Issue | 3 | Pages | 258-65 |
| PubMed ID | 24464130 | Mgi Jnum | J:209441 |
| Mgi Id | MGI:5567867 | Doi | 10.1038/ni.2820 |
| Citation | Waterfield M, et al. (2014) The transcriptional regulator Aire coopts the repressive ATF7ip-MBD1 complex for the induction of immunotolerance. Nat Immunol 15(3):258-65 |
| abstractText | The maintenance of immunological tolerance requires the deletion of self-reactive T cells in the thymus. The expression of genes encoding tissue-specific antigens (TSAs) by thymic epithelial cells is critical for this process and depends on activity of the transcriptional regulator Aire; however, the molecular mechanisms Aire uses to target loci encoding TSAs are unknown. Here we identified two Aire-interacting proteins known to be involved in gene repression, ATF7ip and MBD1, that were required for Aire's targeting of loci encoding TSAs. Moreover, Mbd1(-/-) mice developed pathological autoimmunity and had a defect in Aire-dependent thymic expression of genes encoding TSAs, which underscores the importance of Aire's interaction with the ATF7ip-MBD1 protein complex in maintaining central tolerance. |
