| First Author | Guerau-de-Arellano M | Year | 2009 |
| Journal | J Exp Med | Volume | 206 |
| Issue | 6 | Pages | 1245-52 |
| PubMed ID | 19487417 | Mgi Jnum | J:149510 |
| Mgi Id | MGI:3848624 | Doi | 10.1084/jem.20090300 |
| Citation | Guerau-de-Arellano M, et al. (2009) Neonatal tolerance revisited: a perinatal window for Aire control of autoimmunity. J Exp Med 206(6):1245-52 |
| abstractText | There has long been conceptual and experimental support for, but also challenges to, the notion that the initial period of the immune system's development is particularly important for the establishment of tolerance to self. The display of self-antigens by thymic epithelial cells is key to inducing tolerance in the T lymphocyte compartment, a process enhanced by the Aire transcription factor. Using a doxycycline-regulated transgene to target Aire expression to the thymic epithelium, complementing the Aire knockout in a temporally controlled manner, we find that Aire is essential in the perinatal period to prevent the multiorgan autoimmunity that is typical of Aire deficiency. Surprisingly, Aire could be shut down soon thereafter and remain off for long periods, with few deleterious consequences. The lymphopenic state present in neonates was a factor in this dichotomy because inducing lymphopenia during Aire turnoff in adults recreated the disease, which, conversely, could be ameliorated by supplementing neonates with adult lymphocytes. In short, Aire expression during the perinatal period is both necessary and sufficient to induce long-lasting tolerance and avoid autoimmunity. Aire-controlled mechanisms of central tolerance are largely dispensable in the adult, as a previously tolerized T cell pool can buffer newly generated autoreactive T cells that might emerge. |
