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Allele : Tg(Plp1-cre/ERT2)1Ueli transgene insertion 1, Ueli Suter
Primary Identifier  MGI:2663093 Allele Type  Transgenic
Attribute String  Inducible, Recombinase Gene  Tg(Plp1-cre/ERT2)1Ueli
Strain of Origin  (C57BL/6 x DBA/2)F1 Induced With  tamoxifen
Is Recombinase  true Is Wild Type  false
molecularNote  The transgene consists of a mouse Plp promoter region (exons 1 and 2) and a cre-ESR1 cassette. The human ESR1 sequence is mutated at G400V, M543A, and L540A in the ligand-binding domain to allow activation by 4-hydroxytamoxifen (OHT) and ICI 182,780. 15 kb of mouse Plp promoter sequences drive transgene expression in oligodendrocytes and Schwann cells.
  • mutations:
  • Insertion
  • synonyms:
  • PLP-CreERT2,
  • Tg(Plp1-cre/ESR1)1Ueli,
  • PLP-CreERT2,
  • PLP/Cre-ERT2,
  • Tg(Plp1-cre/ESR1)1Ueli,
  • PLP/Cre-ERT2
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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2 Carried By

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1 Driven By

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59 Publication categories

Trail: Allele




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