| First Author | Lee YH | Year | 2012 |
| Journal | Cell Metab | Volume | 15 |
| Issue | 4 | Pages | 480-91 |
| PubMed ID | 22482730 | Mgi Jnum | J:184459 |
| Mgi Id | MGI:5424065 | Doi | 10.1016/j.cmet.2012.03.009 |
| Citation | Lee YH, et al. (2012) In vivo identification of bipotential adipocyte progenitors recruited by beta3-adrenoceptor activation and high-fat feeding. Cell Metab 15(4):480-91 |
| abstractText | Nutritional and pharmacological stimuli can dramatically alter the cellular phenotypes in white adipose tissue (WAT). Utilizing genetic lineage tracing techniques, we demonstrate that brown adipocytes (BA) that are induced by beta3-adrenergic receptor activation in abdominal WAT arise from the proliferation and differentiation of cells expressing platelet-derived growth factor receptor alpha (PDGFRalpha), CD34, and Sca-1 (PDGFRalpha(+) cells). PDGFRalpha(+) cells have a unique morphology in which extended processes contact multiple cells in the tissue microenvironment. Surprisingly, these cells also give rise to white adipocytes (WA) that can comprise up to 25% of total fat cells in abdominal fat pads following 8 weeks of high-fat feeding. Isolated PDGFRalpha(+) cells differentiated into both BA and WA in vitro and generated WA after transplantation in vivo. The identification of PDGFRalpha(+) cells as bipotential adipocyte progenitors will enable further investigation of mechanisms that promote therapeutic cellular remodeling in adult WAT. |
