| First Author | Özsoy Ş | Year | 2021 |
| Journal | Cell Rep | Volume | 35 |
| Issue | 1 | Pages | 108942 |
| PubMed ID | 33826895 | Mgi Jnum | J:306550 |
| Mgi Id | MGI:6716801 | Doi | 10.1016/j.celrep.2021.108942 |
| Citation | Ozsoy S, et al. (2021) Cannibalized erythroblasts accelerate developmental neurogenesis by regulating mitochondrial dynamics. Cell Rep 35(1):108942 |
| abstractText | Metabolic support was long considered to be the only developmental function of hematopoiesis, a view that is gradually changing. Here, we disclose a mechanism triggered during neurulation that programs brain development by donation of sacrificial yolk sac erythroblasts to neuroepithelial cells. At embryonic day (E) 8.5, neuroepithelial cells transiently integrate with the endothelium of yolk sac blood vessels and cannibalize intravascular erythroblasts as transient heme-rich endosymbionts. This cannibalistic behavior instructs precocious neuronal differentiation of neuroepithelial cells in the proximity of blood vessels. By experiments in vitro, we show that access to erythroblastic heme accelerates the pace of neurogenesis by induction of a truncated neurogenic differentiation program from a poised state. Mechanistically, the poised state is invoked by activation of the mitochondrial electron transport chain that leads to amplified production of reactive oxygen species in addition to omnipresent guanosine triphosphate (GTP) with consequential upregulation of pro-differentiation beta-catenin. |
