| First Author | Humphreys IR | Year | 2010 |
| Journal | Eur J Immunol | Volume | 40 |
| Issue | 10 | Pages | 2762-8 |
| PubMed ID | 20722077 | Mgi Jnum | J:165728 |
| Mgi Id | MGI:4838358 | Doi | 10.1002/eji.200940256 |
| Citation | Humphreys IR, et al. (2010) Biphasic role of 4-1BB in the regulation of mouse cytomegalovirus-specific CD8(+) T cells. Eur J Immunol 40(10):2762-8 |
| abstractText | The initial requirement for the emergence of CMV-specific CD8(+) T cells is poorly understood. Mice deficient in the cosignaling TNF superfamily member, 4-1BB, surprisingly developed exaggerated early CD8(+) T-cell responses to mouse CMV (MCMV). CD8(+) T cells directed against acute MCMV epitopes were enhanced, demonstrating that 4-1BB naturally antagonizes these primary populations. Paradoxically, 4-1BB-deficient mice displayed reduced accumulation of memory CD8(+) T cells that expand during chronic/latent infection. Importantly, the canonical TNF-related ligand, 4-1BBL, promoted the accumulation of these memory CD8(+) T cells, whereas suppression of acute CD8(+) T cells was independent of 4-1BBL. These data highlight the dual nature of the 4-1BB/4-1BBL system in mediating both stimulatory and inhibitory cosignaling activities during the generation of anti-MCMV immunity. |
