| First Author | Lindquist RA | Year | 2016 |
| Journal | Nat Commun | Volume | 7 |
| Pages | 11628 | PubMed ID | 27188978 |
| Mgi Jnum | J:239928 | Mgi Id | MGI:5882032 |
| Doi | 10.1038/ncomms11628 | Citation | Lindquist RA, et al. (2016) Identification of proliferative progenitors associated with prominent postnatal growth of the pons. Nat Commun 7:11628 |
| abstractText | The pons controls crucial sensorimotor and autonomic functions. In humans, it grows sixfold postnatally and is a site of paediatric gliomas; however, the mechanisms of pontine growth remain poorly understood. We show that the murine pons quadruples in volume postnatally; growth is fastest during postnatal days 0-4 (P0-P4), preceding most myelination. We identify three postnatal proliferative compartments: ventricular, midline and parenchymal. We find no evidence of postnatal neurogenesis in the pons, but each progenitor compartment produces new astroglia and oligodendroglia; the latter expand 10- to 18-fold postnatally, and are derived mostly from the parenchyma. Nearly all parenchymal progenitors at P4 are Sox2(+)Olig2(+), but by P8 a Sox2(-) subpopulation emerges, suggesting a lineage progression from Sox2(+) 'early' to Sox2(-) 'late' oligodendrocyte progenitor. Fate mapping reveals that >90% of adult oligodendrocytes derive from P2-P3 Sox2(+) progenitors. These results demonstrate the importance of postnatal Sox2(+)Olig2(+) progenitors in pontine growth and oligodendrogenesis. |
