| First Author | Messing A | Year | 1988 |
| Journal | Oncogene Res | Volume | 3 |
| Issue | 1 | Pages | 87-97 |
| PubMed ID | 3060799 | Mgi Jnum | J:79727 |
| Mgi Id | MGI:2388852 | Citation | Messing A, et al. (1988) Developmental study of SV40 large T antigen expression in transgenic mice with choroid plexus neoplasia. Oncogene Res 3(1):87-97 |
| abstractText | Expression of SV40 large T antigen was correlated with the development of pathology in three lines of transgenic mice. Immunohistochemical detection of large T revealed positive cells only in subsets of choroid plexus epithelium, thymus and renal tubular epithelium, which was first observed during the first month of post-natal life. Morphologic abnormalities became apparent several weeks later. Only some of the choroid plexus cells which expressed T antigen progressed to form neoplasms, suggesting the need for one or more secondary events to effect transformation. Tumors did not develop in thymus and kidney. |
