| First Author | Cannon JL | Year | 2013 |
| Journal | PLoS One | Volume | 8 |
| Issue | 11 | Pages | e78940 |
| PubMed ID | 24250818 | Mgi Jnum | J:283194 |
| Mgi Id | MGI:6242696 | Doi | 10.1371/journal.pone.0078940 |
| Citation | Cannon JL, et al. (2013) PKCtheta regulates T cell motility via ezrin-radixin-moesin localization to the uropod. PLoS One 8(11):e78940 |
| abstractText | Cell motility is a fundamental process crucial for function in many cell types, including T cells. T cell motility is critical for T cell-mediated immune responses, including initiation, activation, and effector function. While many extracellular receptors and cytoskeletal regulators have been shown to control T cell migration, relatively few signaling mediators have been identified that can modulate T cell motility. In this study, we find a previously unknown role for PKCtheta in regulating T cell migration to lymph nodes. PKCtheta localizes to the migrating T cell uropod and regulates localization of the MTOC, CD43 and ERM proteins to the uropod. Furthermore, PKCtheta-deficient T cells are less responsive to chemokine induced migration and are defective in migration to lymph nodes. Our results reveal a novel role for PKCtheta in regulating T cell migration and demonstrate that PKCtheta signals downstream of CCR7 to regulate protein localization and uropod formation. |
