| First Author | Xiong Y | Year | 2012 |
| Journal | J Biol Chem | Volume | 287 |
| Issue | 41 | Pages | 34372-85 |
| PubMed ID | 22896699 | Mgi Jnum | J:191582 |
| Mgi Id | MGI:5462133 | Doi | 10.1074/jbc.M111.325332 |
| Citation | Xiong Y, et al. (2012) Polycomb antagonizes p300/CREB-binding protein-associated factor to silence FOXP3 in a Kruppel-like factor-dependent manner. J Biol Chem 287(41):34372-85 |
| abstractText | Inducible gene expression underlies the epigenetically inherited differentiation program of most immune cells. We report that the promoter of the FOXP3 gene possesses two distinct functional states: an "off state" mediated by the polycomb histone methyltransferase complex and a histone acetyltransferase-dependent "on state." Regulating these states is the presence of a Kruppel-like factor (KLF)-containing Polycomb response element. In the KLF10(-/-) mouse, the FOXP3 promoter is epigenetically silenced by EZH2 (Enhancer of Zeste 2)-mediated trimethylation of Histone 3 K27; thus, impaired FOXP3 induction and inappropriate adaptive T regulatory cell differentiation results in vitro and in vivo. The epigenetic transmittance of adaptive T regulatory cell deficiency is demonstrated throughout more than 40 generations of mice. These results provide insight into chromatin remodeling events key to phenotypic features of distinct T cell populations. |
