| First Author | Liu Z | Year | 2011 |
| Journal | Clin Exp Immunol | Volume | 164 |
| Issue | 3 | Pages | 396-406 |
| PubMed ID | 21438871 | Mgi Jnum | J:172254 |
| Mgi Id | MGI:5005045 | Doi | 10.1111/j.1365-2249.2011.04382.x |
| Citation | Liu Z, et al. (2011) Chemokine CXCL11 links microbial stimuli to intestinal inflammation. Clin Exp Immunol 164(3):396-406 |
| abstractText | Interleukin (IL)-17 plays an important role in the pathogenesis in a number of immune inflammatory disorders. This study aims to investigate the mechanism by which microbial product flagellin is involved in the development of T helper type (Th)17 cells. Serum levels of IL-17 and CXCL9-11 in patients with ulcerative colitis (UC) were evaluated. The source and mechanism of CXC11 release in intestinal mucosa were examined with colonic biopsies from UC patients and a colitis mouse model. The role of flagellin in the development of Th17 cells was studied with a cell co-culture system. High serum levels of CXCL11 and IL-17 were observed in UC. Flagellin could induce the production of CXCL11 in CD14(+) cells that facilitated the development of Th17 cells. In a skewed Th1 response environment flagellin induces intestinal inflammation, with IL-17 expression predominant. CXCR3/CXCL11 pathway is involved in microbial product flagellin-induced intestinal inflammation in which the Th17 response plays an important role. |
