| First Author | Güler ML | Year | 1996 |
| Journal | Science | Volume | 271 |
| Issue | 5251 | Pages | 984-7 |
| PubMed ID | 8584935 | Mgi Jnum | J:31487 |
| Mgi Id | MGI:78995 | Doi | 10.1126/science.271.5251.984 |
| Citation | Guler ML, et al. (1996) Genetic susceptibility to Leishmania: IL-12 responsiveness in TH1 cell development [see comments]. Science 271(5251):984-7 |
| abstractText | The genetic background of T lymphocytes influences development of the T helper (TH) phenotype, resulting in either resistance or susceptibility of certain mouse strains to pathogens such as Leishmania major. With an in vitro model system, a difference in maintenance of responsiveness of T cells to interleukin-12 (IL-12) was detected between BALB/c and B10.D2 mice. Although naive T cells from both strains initially responded to IL-12, BALB/c T cells lost IL-12 responsiveness after stimulation with antigen in vitro, even when cocultured with B10.D2 T cells. Thus, susceptibility of BALB/c mice to infection with L. major may derive from the loss of the ability to generate IL-12-induced TH1 responses rather than from an IL-4-induced TH2 response. |
