| First Author | Wang X | Year | 2013 |
| Journal | Int J Mol Sci | Volume | 14 |
| Issue | 10 | Pages | 20459-77 |
| PubMed ID | 24129179 | Mgi Jnum | J:315871 |
| Mgi Id | MGI:6832336 | Doi | 10.3390/ijms141020459 |
| Citation | Wang X, et al. (2013) Twist and miR-34a are involved in the generation of tumor-educated myeloid-derived suppressor cells. Int J Mol Sci 14(10):20459-77 |
| abstractText | Tumors can induce the generation and accumulation of immunosuppressive cells such as myeloid-derived suppressor cells in the tumor microenvironment, contributing to tumor immunological escapes. Many studies have demonstrated that multiple factors could induce myeloid precursor cells into myeloid-derived suppressor cells, not dendritic cells. In our study, we found that tumor supernatants could induce the generation of myeloid-derived suppressor cells by disturbing the development of dendritic cells. Twist and miR-34a may regulate the effect of tumor cells inducing myeloid-derived suppressor cells via TGF-beta and/or IL-10. |
