| First Author | Jung K | Year | 2022 |
| Journal | Biochem Biophys Res Commun | Volume | 628 |
| Pages | 18-24 | PubMed ID | 36063598 |
| Mgi Jnum | J:328542 | Mgi Id | MGI:7336422 |
| Doi | 10.1016/j.bbrc.2022.08.055 | Citation | Jung K, et al. (2022) VSIG4-expressing tumor-associated macrophages impair anti-tumor immunity. Biochem Biophys Res Commun 628:18-24 |
| abstractText | VSIG4, a newly identified co-inhibitory molecule belonging to the B7-related family, is exclusively expressed on tissue-resident macrophages and is involved in the suppression of T cell proliferation and cytokine production. We sought to characterize the role of VSIG4 in anti-tumor immunity in the tumor microenvironment, focusing on VSIG4-expressing tumor-associated macrophages (TAMs). We found that VSIG4-expressing TAMs negatively regulated antigen-specific T cell proliferation and cytokine production through direct inhibition via cell cycle arrest, but not apoptosis, as well as through their arginase 1 activity. Furthermore, VSIG4-expressing TAMs suppress tumor-specific CD8(+) T cell cytotoxicity. Therefore, our results suggest that VSIG4-expressing TAMs could be a negative cellular regulator of anti-tumor immunity in the tumor microenvironment. |
