| First Author | Ye Q | Year | 2002 |
| Journal | J Exp Med | Volume | 196 |
| Issue | 1 | Pages | 87-95 |
| PubMed ID | 12093873 | Mgi Jnum | J:77507 |
| Mgi Id | MGI:2181903 | Doi | 10.1084/jem.20012084 |
| Citation | Ye Q, et al. (2002) T cell costimulation through CD28 depends on induction of the Bcl-xgamma isoform: analysis of Bcl-xgamma-deficient mice. J Exp Med 196(1):87-95 |
| abstractText | The molecular basis of CD28-dependent costimulation of T cells is poorly understood. Bcl-xgamma is a member of the Bcl-x family whose expression is restricted to activated T cells and requires CD28-dependent ligation for full expression. We report that Bcl-xgamma-deficient (Bcl-xgamma-/-) T cells display defective proliferative and cytokine responses to CD28-dependent costimulatory signals, impaired memory responses to proteolipid protein peptide (PLP), and do not develop PLP-induced experimental autoimmune encephalomyelitis (EAE). In contrast, enforced expression of Bcl-xgamma largely replaces the requirement for B7-dependent ligation of CD28. These findings identify the Bcl-xgamma cytosolic protein as an essential downstream link in the CD28-dependent signaling pathway that underlies T cell costimulation. |
