| First Author | Schweier O | Year | 2019 |
| Journal | Eur J Immunol | Volume | 49 |
| Issue | 4 | Pages | 626-637 |
| PubMed ID | 30636035 | Mgi Jnum | J:277146 |
| Mgi Id | MGI:6317153 | Doi | 10.1002/eji.201847772 |
| Citation | Schweier O, et al. (2019) Residual LCMV antigen in transiently CD4(+) T cell-depleted mice induces high levels of virus-specific antibodies but only limited B-cell memory. Eur J Immunol 49(4):626-637 |
| abstractText | Infection of C57BL/6 mice with lymphocytic choriomeningitis virus (LCMV) strain Armstrong (Arm) induces an acute infection with rapid virus clearance by CD8(+) T cells independently of CD4(+) T cell help. Residual viral antigen may, however, persist for a prolonged time. Here, we demonstrate that mice that had been transiently depleted of CD4(+) T cells during acute LCMV Arm infection generated high levels of virus-specific IgG antibodies (Ab) after viral clearance. Robust induction of LCMV-specific IgG after transient CD4(+) T cell depletion was dependent on Fcgamma receptors but not on the complement receptors CD21/CD35. In contrast to the potent production of LCMV-specific IgG, the generation of LCMV-specific isotype-switched memory B cells after transient CD4(+) T cell depletion was considerably reduced. Moreover, mice depleted of CD4(+) T cells during acute infection were strongly impaired in generating a secondary LCMV-specific B cell response upon LCMV rechallenge. In conclusion, our data indicate that LCMV antigen depots after viral clearance were capable of inducing high levels of virus-specific IgG. They failed, however, to induce robust virus-specific B cell memory revealing a previously unappreciated dichotomy of specific Ab production and memory cell formation after priming with residual antigen. |
