| First Author | Uehara S | Year | 2002 |
| Journal | J Immunol | Volume | 168 |
| Issue | 6 | Pages | 2811-9 |
| PubMed ID | 11884450 | Mgi Jnum | J:110846 |
| Mgi Id | MGI:3641388 | Doi | 10.4049/jimmunol.168.6.2811 |
| Citation | Uehara S, et al. (2002) A role for CCR9 in T lymphocyte development and migration. J Immunol 168(6):2811-9 |
| abstractText | CCR9 mediates chemotaxis in response to CCL25/thymus-expressed chemokine and is selectively expressed on T cells in the thymus and small intestine. To investigate the role of CCR9 in T cell development, the CCR9 gene was disrupted by homologous recombination. B cell development, thymic alphabeta-T cell development, and thymocyte selection appeared unimpaired in adult CCR9-deficient (CCR9(-/-)) mice. However, competitive transplantation experiments revealed that bone marrow from CCR9(-/-) mice was less efficient at repopulating the thymus of lethally irradiated Rag-1(-/-) mice than bone marrow from littermate CCR9(+/+) mice. CCR9(-/-) mice had increased numbers of peripheral gammadelta-T cells but reduced numbers of gammadeltaTCR(+) and CD8alphabeta(+)alphabetaTCR(+) intraepithelial lymphocytes in the small intestine. Thus, CCR9 plays an important, although not indispensable, role in regulating the development and/or migration of both alphabeta(-) and gammadelta(-) T lymphocytes. |
