| First Author | Dejean AS | Year | 2009 |
| Journal | Nat Immunol | Volume | 10 |
| Issue | 5 | Pages | 504-13 |
| PubMed ID | 19363483 | Mgi Jnum | J:148279 |
| Mgi Id | MGI:3844180 | Doi | 10.1038/ni.1729 |
| Citation | Dejean AS, et al. (2009) Transcription factor Foxo3 controls the magnitude of T cell immune responses by modulating the function of dendritic cells. Nat Immunol 10(5):504-13 |
| abstractText | Foxo transcription factors regulate cell cycle progression, cell survival and DNA-repair pathways. Here we demonstrate that deficiency in Foxo3 resulted in greater expansion of T cell populations after viral infection. This exaggerated expansion was not T cell intrinsic. Instead, it was caused by the enhanced capacity of Foxo3-deficient dendritic cells to sustain T cell viability by producing more interleukin 6. Stimulation of dendritic cells mediated by the coinhibitory molecule CTLA-4 induced nuclear localization of Foxo3, which in turn inhibited the production of interleukin 6 and tumor necrosis factor. Thus, Foxo3 acts to constrain the production of key inflammatory cytokines by dendritic cells and to control T cell survival. |
