| First Author | Ban YH | Year | 2017 |
| Journal | Cell Rep | Volume | 20 |
| Issue | 11 | Pages | 2598-2611 |
| PubMed ID | 28903041 | Mgi Jnum | J:254195 |
| Mgi Id | MGI:6104209 | Doi | 10.1016/j.celrep.2017.08.065 |
| Citation | Ban YH, et al. (2017) miR-150-Mediated Foxo1 Regulation Programs CD8(+) T Cell Differentiation. Cell Rep 20(11):2598-2611 |
| abstractText | MicroRNA (miR)-150 is a developmental regulator of several immune-cell types, but its role in CD8(+) T cells is largely unexplored. Here, we show that miR-150 regulates the generation of memory CD8(+) T cells. After acute virus infection, miR-150 knockout (KO) mice exhibited an accelerated differentiation of CD8(+) T cells into memory cells and improved production of effector cytokines. Additionally, miR-150 KO CD8(+) T cells displayed an enhanced recall response and improved protection against infections with another virus and bacteria. We found that forkhead box O1 (Foxo1) and T cell-specific transcription factor 1 (TCF1) are upregulated during the early activation phase in miR-150 KO CD8(+) T cells and that miR-150 directly targets and suppresses Foxo1. These results suggest that miR-150-mediated suppression of Foxo1 regulates the balance between effector and memory cell differentiation, which might aid in the development of improved vaccines and T cell therapeutics. |
