| First Author | Dudda JC | Year | 2013 |
| Journal | Immunity | Volume | 38 |
| Issue | 4 | Pages | 742-53 |
| PubMed ID | 23601686 | Mgi Jnum | J:196960 |
| Mgi Id | MGI:5490401 | Doi | 10.1016/j.immuni.2012.12.006 |
| Citation | Dudda JC, et al. (2013) MicroRNA-155 is required for effector CD8+ T cell responses to virus infection and cancer. Immunity 38(4):742-53 |
| abstractText | MicroRNAs (miRNAs) regulate the function of several immune cells, but their role in promoting CD8(+) T cell immunity remains unknown. Here we report that miRNA-155 is required for CD8(+) T cell responses to both virus and cancer. In the absence of miRNA-155, accumulation of effector CD8(+) T cells was severely reduced during acute and chronic viral infections and control of virus replication was impaired. Similarly, Mir155(-/-) CD8(+) T cells were ineffective at controlling tumor growth, whereas miRNA-155 overexpression enhanced the antitumor response. miRNA-155 deficiency resulted in accumulation of suppressor of cytokine signaling-1 (SOCS-1) causing defective cytokine signaling through STAT5. Consistently, enforced expression of SOCS-1 in CD8(+) T cells phenocopied the miRNA-155 deficiency, whereas SOCS-1 silencing augmented tumor destruction. These findings identify miRNA-155 and its target SOCS-1 as key regulators of effector CD8(+) T cells that can be modulated to potentiate immunotherapies for infectious diseases and cancer. |
