| First Author | Dimitriou ID | Year | 2018 |
| Journal | Cell Rep | Volume | 24 |
| Issue | 5 | Pages | 1123-1135 |
| PubMed ID | 30067970 | Mgi Jnum | J:270763 |
| Mgi Id | MGI:6278700 | Doi | 10.1016/j.celrep.2018.06.075 |
| Citation | Dimitriou ID, et al. (2018) Timed Regulation of 3BP2 Induction Is Critical for Sustaining CD8(+) T Cell Expansion and Differentiation. Cell Rep 24(5):1123-1135 |
| abstractText | Successful anti-viral response requires the sustained activation and expansion of CD8(+) T cells for periods that far exceed the time limit of physical T cell interaction with antigen-presenting cells (APCs). The expanding CD8(+) T cell pool generates the effector and memory cell populations that provide viral clearance and long-term immunity, respectively. Here, we demonstrate that 3BP2 is recruited in cytoplasmic microclusters and nucleates a signaling complex that facilitates MHC:peptide-independent activation of signaling pathways downstream of the TCR. We show that induction of the adaptor molecule 3BP2 is a sensor of TCR signal strength and is critical for sustaining CD8(+) T cell proliferation and regulating effector and memory differentiation. |
