| First Author | Shin J | Year | 2012 |
| Journal | J Immunol | Volume | 188 |
| Issue | 5 | Pages | 2111-7 |
| PubMed ID | 22271650 | Mgi Jnum | J:181278 |
| Mgi Id | MGI:5310688 | Doi | 10.4049/jimmunol.1102265 |
| Citation | Shin J, et al. (2012) Differential regulation of primary and memory CD8 T cell immune responses by diacylglycerol kinases. J Immunol 188(5):2111-7 |
| abstractText | The manipulation of signals downstream of the TCR can have profound consequences for T cell development, function, and homeostasis. Diacylglycerol (DAG) produced after TCR stimulation functions as a secondary messenger and mediates the signaling to Ras-MEK-Erk and NF-kappaB pathways in T cells. DAG kinases (DGKs) convert DAG into phosphatidic acid, resulting in termination of DAG signaling. In this study, we demonstrate that DAG metabolism by DGKs can serve a crucial function in viral clearance upon lymphocytic choriomeningitis virus infection. Ag-specific CD8(+) T cells from DGKalpha(-/-) and DGKzeta(-/-) mice show enhanced expansion and increased cytokine production after lymphocytic choriomeningitis virus infection, yet DGK-deficient memory CD8(+) T cells exhibit impaired expansion after rechallenge. Thus, DGK activity plays opposing roles in the expansion of CD8(+) T cells during the primary and memory phases of the immune response, whereas consistently inhibiting antiviral cytokine production. |
