| First Author | Ichinohe M | Year | 2007 |
| Journal | Biochem Biophys Res Commun | Volume | 356 |
| Issue | 4 | Pages | 912-8 |
| PubMed ID | 17397799 | Mgi Jnum | J:121619 |
| Mgi Id | MGI:3710735 | Doi | 10.1016/j.bbrc.2007.03.082 |
| Citation | Ichinohe M, et al. (2007) Lack of phospholipase C-delta1 induces skin inflammation. Biochem Biophys Res Commun 356(4):912-8 |
| abstractText | Phospholipase C (PLC) is a key enzyme in phosphoinositide signaling. We previously generated PLC-delta1 knockout (KO) mice and found that these mice showed remarkable hair loss caused by abnormalities in hair follicle structures. Here we show that the skin of PLC-delta1 KO mice displays typical inflammatory phenotypes, including increased dermal cellularity, leukocyte infiltration, and expression of pro-inflammatory cytokines. In addition, exogenously expressed PLC-delta1 attenuates lipopolysaccharide-induced expression of IL-1beta, a pro-inflammatory cytokine, in an enzymatic activity-dependent manner. Furthermore, suppression of skin inflammation by anti-inflammatory reagents cured the epidermal hyperplasia in PLC-delta1 KO mice. Taken together, these results indicate that lack of PLC-delta1 induces skin inflammation and that the epidermal hyperplasia in PLC-delta1 KO mice is caused by skin inflammation. Our results also suggest that PLC-delta1 regulates homeostasis of the immune system in skin. |
