| First Author | Liu J | Year | 2003 |
| Journal | Int Immunol | Volume | 15 |
| Issue | 7 | Pages | 861-70 |
| PubMed ID | 12807825 | Mgi Jnum | J:84366 |
| Mgi Id | MGI:2667494 | Doi | 10.1093/intimm/dxg082 |
| Citation | Liu J, et al. (2003) LIGHT-deficiency impairs CD8+ T cell expansion, but not effector function. Int Immunol 15(7):861-70 |
| abstractText | LIGHT, a newly identified member of the tumor necrosis factor (TNF) family, is expressed on activated T lymphocytes. To evaluate how LIGHT contributes to T cell functions, we generated LIGHT-deficient (LIGHT(-/-)) mice using gene targeting. Disruption of LIGHT significantly reduced CD8(+) T cell-cycle progression, leading to reduced proliferation to anti-CD3, anti-CD3/anti-CD28 or allogeneic stimulation, whereas proliferation of CD4(+) T cells remained unchanged. In contrast to the observed proliferative defects, isolated CD8(+) T cells from LIGHT(-/-) mice displayed normal cytotoxic effector function development when compared to wild-type CD8(+) T cells. Underlying a potential mechanism of reduced CD8(+) T cell proliferation, LIGHT(-/-) CD8(+) T cells displayed reduced surface levels of CD25 and a diminished ability to proliferate in response to exogenous IL-2. Furthermore, addition of IL-12 to LIGHT(-/-) CD8(+) T cell cultures could not ameliorate this proliferative defect. These results reveal a potential mechanism of action for LIGHT as a positive regulator of CD8(+) T cell expansion, but not lytic effector function development. |
