| First Author | Tsyporin J | Year | 2021 |
| Journal | Cell Rep | Volume | 35 |
| Issue | 12 | Pages | 109269 |
| PubMed ID | 34161768 | Mgi Jnum | J:306633 |
| Mgi Id | MGI:6717195 | Doi | 10.1016/j.celrep.2021.109269 |
| Citation | Tsyporin J, et al. (2021) Transcriptional repression by FEZF2 restricts alternative identities of cortical projection neurons. Cell Rep 35 |
| abstractText | Projection neuron subtype identities in the cerebral cortex are established by expressing pan-cortical and subtype-specific effector genes that execute terminal differentiation programs bestowing neurons with a glutamatergic neuron phenotype and subtype-specific morphology, physiology, and axonal projections. Whether pan-cortical glutamatergic and subtype-specific characteristics are regulated by the same genes or controlled by distinct programs remains largely unknown. Here, we show that FEZF2 functions as a transcriptional repressor, and it regulates subtype-specific identities of both corticothalamic and subcerebral neurons by selectively repressing expression of genes inappropriate for each neuronal subtype. We report that TLE4, specifically expressed in layer 6 corticothalamic neurons, is recruited by FEZF2 to inhibit layer 5 subcerebral neuronal genes. Together with previous studies, our results indicate that a cortical glutamatergic identity is specified by multiple parallel pathways active in progenitor cells, whereas projection neuron subtype-specific identity is achieved through selectively repressing genes associated with alternate identities in differentiating neurons. |
