| First Author | Beed P | Year | 2020 |
| Journal | Cell Rep | Volume | 33 |
| Issue | 10 | Pages | 108470 |
| PubMed ID | 33296656 | Mgi Jnum | J:317449 |
| Mgi Id | MGI:6706261 | Doi | 10.1016/j.celrep.2020.108470 |
| Citation | Beed P, et al. (2020) Layer 3 Pyramidal Cells in the Medial Entorhinal Cortex Orchestrate Up-Down States and Entrain the Deep Layers Differentially. Cell Rep 33(10):108470 |
| abstractText | Up-down states (UDS) are synchronous cortical events of neuronal activity during non-REM sleep. The medial entorhinal cortex (MEC) exhibits robust UDS during natural sleep and under anesthesia. However, little is known about the generation and propagation of UDS-related activity in the MEC. Here, we dissect the circuitry underlying UDS generation and propagation across layers in the MEC using both in vivo and in vitro approaches. We provide evidence that layer 3 (L3) MEC is crucial in the generation and maintenance of UDS in the MEC. Furthermore, we find that the two sublayers of the L5 MEC participate differentially during UDS. Our findings show that L5b, which receives hippocampal output, is strongly innervated by UDS activity originating in L3 MEC. Our data suggest that L5b acts as a coincidence detector during information transfer between the hippocampus and the cortex and thereby plays an important role in memory encoding and consolidation. |
