| First Author | Kabashima K | Year | 2003 |
| Journal | Nat Immunol | Volume | 4 |
| Issue | 7 | Pages | 694-701 |
| PubMed ID | 12778172 | Mgi Jnum | J:84085 |
| Mgi Id | MGI:2665195 | Doi | 10.1038/ni943 |
| Citation | Kabashima K, et al. (2003) Thromboxane A2 modulates interaction of dendritic cells and T cells and regulates acquired immunity. Nat Immunol 4(7):694-701 |
| abstractText | Physical interaction of T cells and dendritic cells (DCs) is essential for T cell proliferation and differentiation, but it has been unclear how this interaction is regulated physiologically. Here we show that DCs produce thromboxane A2 (TXA2), whereas naive T cells express the thromboxane receptor (TP). In vitro, a TP agonist enhances random cell movement (chemokinesis) of naive but not memory T cells, impairs DC-T cell adhesion, and inhibits DC-dependent proliferation of T cells. In vivo, immune responses to foreign antigens are enhanced in TP-deficient mice, which also develop marked lymphadenopathy with age. Similar immune responses were seen in wild-type mice treated with a TP antagonist during the sensitization period. Thus, TXA2-TP signaling modulates acquired immunity by negatively regulating DC-T cell interactions. |
