| First Author | Herzog S | Year | 2008 |
| Journal | Nat Immunol | Volume | 9 |
| Issue | 6 | Pages | 623-31 |
| PubMed ID | 18488031 | Mgi Jnum | J:136355 |
| Mgi Id | MGI:3796024 | Doi | 10.1038/ni.1616 |
| Citation | Herzog S, et al. (2008) SLP-65 regulates immunoglobulin light chain gene recombination through the PI(3)K-PKB-Foxo pathway. Nat Immunol 9(6):623-31 |
| abstractText | Although the essential role of the adaptor protein SLP-65 in pre-B cell differentiation is established, the molecular mechanism underlying its function is poorly understood. In this study, we uncover a link between SLP-65-dependent signaling and the phosphoinositide-3-OH kinase (PI(3)K)-protein kinase B (PKB)-Foxo pathway. We show that the forkhead box transcription factor Foxo3a promotes light chain rearrangement in pre-B cells. Our data suggest that PKB suppresses light chain recombination by phosphorylating Foxo proteins, whereas reconstitution of SLP-65 function counteracts PKB activation and promotes Foxo3a and Foxo1 activity in pre-B cells. Together, these data illuminate a molecular function of SLP-65 and identify a key role for Foxo proteins in the regulation of light chain recombination, receptor editing and B cell selection. |
