| First Author | Jeanneteau F | Year | 2010 |
| Journal | Nat Neurosci | Volume | 13 |
| Issue | 11 | Pages | 1373-9 |
| PubMed ID | 20935641 | Mgi Jnum | J:166927 |
| Mgi Id | MGI:4850208 | Doi | 10.1038/nn.2655 |
| Citation | Jeanneteau F, et al. (2010) The MAP kinase phosphatase MKP-1 regulates BDNF-induced axon branching. Nat Neurosci 13(11):1373-9 |
| abstractText | The refinement of neural circuits during development depends on a dynamic process of branching of axons and dendrites that leads to synapse formation and connectivity. The neurotrophin brain-derived neurotrophic factor (BDNF) is essential for the outgrowth and activity-dependent remodeling of axonal arbors in vivo. However, the mechanisms that translate extracellular signals into the formation of axonal branches are incompletely understood. We found that MAP kinase phosphatase-1 (MKP-1) controls axon branching. MKP-1 expression induced by BDNF signaling caused spatiotemporal deactivation of c-jun N-terminal kinase (JNK), which reduced the phosphorylation of JNK substrates that destabilize microtubules. Indeed, neurons from mkp-1 null mice could not produce axon branches in response to BDNF. Our results identify a signaling mechanism that regulates axonal branching and provide a framework for studying the molecular mechanisms of innervation and axonal remodeling under normal and pathological conditions. |
