| First Author | Yao H | Year | 2014 |
| Journal | Nat Commun | Volume | 5 |
| Pages | 4386 | PubMed ID | 25019481 |
| Mgi Jnum | J:288108 | Mgi Id | MGI:6213865 |
| Doi | 10.1038/ncomms5386 | Citation | Yao H, et al. (2014) MiR-9 promotes microglial activation by targeting MCPIP1. Nat Commun 5:4386 |
| abstractText | Microglia participate in innate inflammatory responses within the central nervous system. The highly conserved microRNA-9 (miR-9) plays critical roles in neurogenesis as well as axonal extension. Its role in microglial inflammatory responses, however, remains poorly understood. Here we identify a unique role of miR-9 in mediating the microglial inflammatory response via distinct signalling pathways. MiR-9-mediated regulation of cellular activation involved downregulated expression of the target protein, monocyte chemotactic protein-induced protein 1 (MCPIP1) that is crucial for controlling inflammation. Results indicate that miR-9-mediated cellular activation involved signalling via the NF-kappaB pathway, but not the beta-catenin pathway. |
