| First Author | Rodero MP | Year | 2015 |
| Journal | Elife | Volume | 4 |
| Pages | e07847 | PubMed ID | 26167653 |
| Mgi Jnum | J:225982 | Mgi Id | MGI:5695412 |
| Doi | 10.7554/eLife.07847 | Citation | Rodero MP, et al. (2015) Immune surveillance of the lung by migrating tissue monocytes. Elife 4:e07847 |
| abstractText | Monocytes are phagocytic effector cells in the blood and precursors of resident and inflammatory tissue macrophages. The aim of the current study was to analyse and compare their contribution to innate immune surveillance of the lung in the steady state with macrophage and dendritic cells (DC). ECFP and EGFP transgenic reporters based upon Csf1r and Cx3cr1 distinguish monocytes from resident mononuclear phagocytes. We used these transgenes to study the migratory properties of monocytes and macrophages by functional imaging on explanted lungs. Migratory monocytes were found to be either patrolling within large vessels of the lung or locating at the interface between lung capillaries and alveoli. This spatial organisation gives to monocytes the property to capture fluorescent particles derived from both vascular and airway routes. We conclude that monocytes participate in steady-state surveillance of the lung, in a way that is complementary to resident macrophages and DC, without differentiating into macrophages. |
