| First Author | Liu Y | Year | 2021 |
| Journal | Front Cell Neurosci | Volume | 15 |
| Pages | 651827 | PubMed ID | 33815067 |
| Mgi Jnum | J:329688 | Mgi Id | MGI:6808844 |
| Doi | 10.3389/fncel.2021.651827 | Citation | Liu Y, et al. (2021) Myelin Debris Stimulates NG2/CSPG4 Expression in Bone Marrow-Derived Macrophages in the Injured Spinal Cord. Front Cell Neurosci 15:651827 |
| abstractText | Although the increased expression of members of the chondroitin sulfate proteoglycan family, such as neuron-glial antigen 2 (NG2), have been well documented after an injury to the spinal cord, a complete picture as to the cellular origins and function of this NG2 expression has yet to be made. Using a spinal cord injury (SCI) mouse model, we describe that some infiltrated bone marrow-derived macrophages (BMDMPhi) are early contributors to NG2/CSPG4 expression and secretion after SCI. We demonstrate for the first time that a lesion-related form of cellular debris generated from damaged myelin sheaths can increase NG2/CSPG4 expression in BMDMPhi, which then exhibit enhanced proliferation and decreased phagocytic capacity. These results suggest that BMDMPhi may play a much more nuanced role in secondary spinal cord injury than previously thought, including acting as early contributors to the NG2 component of the glial scar. |
