| First Author | Metharom P | Year | 2010 |
| Journal | Arterioscler Thromb Vasc Biol | Volume | 30 |
| Issue | 3 | Pages | 533-5 |
| PubMed ID | 20007909 | Mgi Jnum | J:346603 |
| Mgi Id | MGI:7617169 | Doi | 10.1161/ATVBAHA.109.200097 |
| Citation | Metharom P, et al. (2010) A specific subset of mouse bone marrow cells has smooth muscle cell differentiation capacity-brief report. Arterioscler Thromb Vasc Biol 30(3):533-5 |
| abstractText | OBJECTIVE: To determine whether CX(3)CR1(+) bone marrow cells have the capacity for smooth muscle cell (SMC) differentiation. METHODS AND RESULTS: CX(3)CR1(+) and CX(3)CR1(-) cells were isolated from marrow of CX(3)CR1 transgenic mice and cultured in SMC differentiation media. Phenotypic and functional analyses showed only CX(3)CR1(+) bone marrow cells exhibit colony cell outgrowth with SMC-specific protein expression, calcium signaling, and contraction responses similar to mature SMC. CONCLUSIONS: CX(3)CR1 marks a bone marrow cells population that enriches for progenitors with capacity to differentiate in vitro into SMC-like cells. |
