| First Author | Msallam R | Year | 2020 |
| Journal | Science | Volume | 370 |
| Issue | 6519 | Pages | 941-950 |
| PubMed ID | 33122426 | Mgi Jnum | J:297655 |
| Mgi Id | MGI:6479149 | Doi | 10.1126/science.aba0864 |
| Citation | Msallam R, et al. (2020) Fetal mast cells mediate postnatal allergic responses dependent on maternal IgE. Science 370(6519):941-950 |
| abstractText | Mast cells (MCs) are central effector cells in allergic reactions that are often mediated by immunoglobulin E (IgE). Allergies commonly start at an early age, and both MCs and IgE are detectable in fetuses. However, the origin of fetal IgE and whether fetal MCs can degranulate in response to IgE-dependent activation are presently unknown. Here, we show that human and mouse fetal MCs phenotypically mature through pregnancy and can be sensitized by maternal IgE. IgE crossed the placenta, dependent on the fetal neonatal Fc receptor (FcRN), and sensitized fetal MCs for allergen-specific degranulation. Both passive and active prenatal sensitization conferred allergen sensitivity, resulting in postnatal skin and airway inflammation after the first allergen encounter. We report a role for MCs within the developing fetus and demonstrate that fetal MCs may contribute to antigen-specific vertical transmission of allergic disease. |
