| First Author | Schoch KM | Year | 2016 |
| Journal | Neuron | Volume | 90 |
| Issue | 5 | Pages | 941-7 |
| PubMed ID | 27210553 | Mgi Jnum | J:240208 |
| Mgi Id | MGI:5882654 | Doi | 10.1016/j.neuron.2016.04.042 |
| Citation | Schoch KM, et al. (2016) Increased 4R-Tau Induces Pathological Changes in a Human-Tau Mouse Model. Neuron 90(5):941-7 |
| abstractText | Pathological evidence for selective four-repeat (4R) tau deposition in certain dementias and exon 10-positioned MAPT mutations together suggest a 4R-specific role in causing disease. However, direct assessments of 4R toxicity have not yet been accomplished in vivo. Increasing 4R-tau expression without change to total tau in human tau-expressing mice induced more severe seizures and nesting behavior abnormality, increased tau phosphorylation, and produced a shift toward oligomeric tau. Exon 10 skipping could also be accomplished in vivo, providing support for a 4R-tau targeted approach to target 4R-tau toxicity and, in cases of primary MAPT mutation, eliminate the disease-causing mutation. |
