| First Author | Andorfer C | Year | 2003 |
| Journal | J Neurochem | Volume | 86 |
| Issue | 3 | Pages | 582-90 |
| PubMed ID | 12859672 | Mgi Jnum | J:84638 |
| Mgi Id | MGI:2668772 | Doi | 10.1046/j.1471-4159.2003.01879.x |
| Citation | Andorfer C, et al. (2003) Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms. J Neurochem 86(3):582-90 |
| abstractText | Neurofibrillary tangles are composed of insoluble aggregates of the microtubule-associated protein tau. In Alzheimer's disease the accumulation of neurofibrillary tangles occurs in the absence of tau mutations. Here we present mice that develop pathology from non-mutant human tau, in the absence of other exogenous factors, including beta-amyloid. The pathology in these mice is Alzheimer-like, with hyperphosphorylated tau accumulating as aggregated paired helical filaments. This pathologic tau accumulates in the cell bodies and dendrites of neurons in a spatiotemporally relevant distribution. |
