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Allele : Kmt2a<T(4Mllt3;9Mll)1Thr> lysine (K)-specific methyltransferase 2A; reciprocal translocation 1, Ch 4 and Ch 9, Terrence H Rabbitts
Primary Identifier  MGI:2671705 Allele Type  Targeted
Gene  Kmt2a Transmission  Germline
Strain of Origin  129S/SvEv-Gpi1<c> Is Recombinase  false
Is Wild Type  false
molecularNote  The T(4Mllt3;9Mll)1Thr translocation was engineered to recapitulate the leukemia-associated human T(9;11)(p22;q23) translocation. The translocation was generated by interchromosomal cre mediated recombination of single loxP sites within Mlltm1Thr and Mllt3tm2Thr. Fusion transcript containing exon 8 of Mll and exon b of Mllt3 was identified in various tissues of mutant mice by RT-PCR analysis.
  • mutations:
  • Translocation
  • synonyms:
  • t(4;9) Mll-AF9 fusion,
  • t(4;9) Mll-AF9 fusion
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1 Feature

Trail: Allele

Genome

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0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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Trail: Allele




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