| Primary Identifier | MGI:2671870 | Allele Type | Chemically induced (ENU) |
| Attribute String | Hypomorph | Gene | Wdr1 |
| Inheritance Mode | Recessive | Strain of Origin | C57BL/6J |
| Is Recombinase | false | Is Wild Type | false |
| Project Collection | Mutagenesis for Dev. Defects |
| molecularNote | This phenotypic mutant was identified in an ENU mutagenesis screen at the Baylor College of Medicine. The molecular lesion is a T-to-A transversion mutation in the second dinucleotide of the intron 9 splice donor. Splicing of the normal trancript is reduced to 20-30% and an aberrant transcript using a cryptic site is expressed. While a small amount of wild-type protein is expressed, the aberrent transcript is predicted to express a mutant protein that lacks 2 amino acids from the sixth WD40 repeat. This mutation is hypomorphic. |
