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Allele : Kmt2a<tm2(MLLT3)Thr> lysine (K)-specific methyltransferase 2A; targeted mutation 2, Terence H Rabbitts
Primary Identifier  MGI:2671905 Allele Type  Targeted
Attribute String  Humanized sequence, Inserted expressed sequence Gene  Kmt2a
Transmission  Germline Strain of Origin  129P2/OlaHsd
Is Recombinase  false Is Wild Type  false
molecularNote  Sequence encoding a 3' portion of human MLLT3 extending from nucleotide 1634 to the translation terminus replaced a 3' portion of murine Kmt2a exon 8. A downstream neo cassette was also included in the targeting vector for selection. The resultant fusion product putatively recapitulates the KMT2A(MLL)/MLLT3 protein produced in patients with the acute myeloid leukamia (AML) associated transloaction T(9;11)(p22;q23).
  • mutations:
  • Insertion
  • synonyms:
  • Mll-AF9<+>,
  • Mll<af9>,
  • Mll-AF9<+>,
  • Mll<af9>,
  • Mll1<tm2Thr>,
  • Mll1<tm2Thr>
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1 Feature

Trail: Allele

Genome

1 Expresses

Trail: Allele

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

Trail: Allele

0 Driven By

28 Publication categories

Trail: Allele




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