| First Author | Magnusson SE | Year | 2009 |
| Journal | FASEB J | Volume | 23 |
| Issue | 3 | Pages | 875-82 |
| PubMed ID | 19010978 | Mgi Jnum | J:146090 |
| Mgi Id | MGI:3836679 | Doi | 10.1096/fj.08-120394 |
| Citation | Magnusson SE, et al. (2009) Mast cell chymase contributes to the antibody response and the severity of autoimmune arthritis. FASEB J 23(3):875-82 |
| abstractText | Mast cells are implicated in rheumatoid arthritis, but the mechanism by which they contribute to disease progression is not clarified. Here we investigated whether mouse mast cell protease-4 (mMCP-4), a chymase present in the mast cell secretory granule, contributes to experimental arthritis. Two models of arthritis were investigated in mMCP-4(+/+) and mMCP-4(-/-) DBA/1 mice: collagen-induced arthritis (CIA) was induced by immunization with collagen II (CII) in Freund's complete adjuvant, and a passive model of arthritis was induced by administration of anti-CII antibodies. The clinical scores were significantly reduced in the mMCP-4(-/-) animals as compared to mMCP-4(+/+) controls in both arthritis models. In CIA, the number of affected paws was lower in the CII-immunized mMCP-4(-/-) mice, with less cartilage destruction, pannus formation, and mononuclear cell and mast cell influx in the mMCP-4(-/-) joints. Interestingly, the lower clinical scores in the CII-immunized mMCP-4(-/-) mice coincided with lower serum levels of immunoglobulin G anti-CII antibodies. Our findings identify a pathogenic role of mMCP-4 in autoimmune arthritis. |
