Primary Identifier | MGI:2674095 | Allele Type | Targeted |
Attribute String | Null/knockout, Reporter | Gene | Fanca |
Transmission | Germline | Strain of Origin | 129S6/SvEvTac |
Is Recombinase | false | Is Wild Type | false |
molecularNote | The floxed neo cassette was removed from Fancatm1Wong via cre-mediated recombination, leaving the IRES-NLS-lacZ sequence in place of exons 1 through 6. While transcript containing the targeted exons was undetected, RT-PCR analysis of homozygous mutant mice revealed transcript that included exons 14 through 18. A C-terminal antibody was not available to determine if protein was produced from the detected message. |