| Primary Identifier | MGI:2673586 | Allele Type | Targeted |
| Attribute String | Humanized sequence, Inserted expressed sequence, Null/knockout | Gene | Egfr |
| Transmission | Germline | Strain of Origin | 129/Sv |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Floxed human cDNA encoding EGFR was inserted at the endogenous locus via homologous recombination. A RSV-neo cassette was inserted downstream of the human sequence. While endogenous levels of the human transcript were detected in brain tissue by RNAse protection, hypomorphic expression was observed in bone and epithelial tissue, putatively due to an effect of the downstream neo cassette. |
