| First Author | Meng Q | Year | 2014 |
| Journal | Dev Biol | Volume | 395 |
| Issue | 1 | Pages | 29-37 |
| PubMed ID | 25224220 | Mgi Jnum | J:216505 |
| Mgi Id | MGI:5608927 | Doi | 10.1016/j.ydbio.2014.09.001 |
| Citation | Meng Q, et al. (2014) Epithelial sheet movement requires the cooperation of c-Jun and MAP3K1. Dev Biol 395(1):29-37 |
| abstractText | Epithelial sheet movement is an essential morphogenetic process during mouse embryonic eyelid closure in which Mitogen-Activated Protein 3 Kinase 1 (MAP3K1) and c-Jun play a critical role. Here we show that MAP3K1 associates with the cytoskeleton, activates Jun N-terminal kinase (JNK) and actin polymerization, and promotes the eyelid inferior epithelial cell elongation and epithelium protrusion. Following epithelium protrusion, c-Jun begins to express and acts to promote ERK phosphorylation and migration of the protruding epithelial cells. Homozygous deletion of either gene causes defective eyelid closure, but non-allelic non-complementation does not occur between Map3k1 and c-Jun and the double heterozygotes have normal eyelid closure. Results from this study suggest that MAP3K1 and c-Jun signal through distinct temporal-spatial pathways and that productive epithelium movement for eyelid closure requires the consecutive action of MAP3K1-dependent cytoskeleton reorganization followed by c-Jun-mediated migration. |
