| Primary Identifier | MGI:2674077 | Allele Type | Targeted |
| Attribute String | Null/knockout, Reporter | Gene | Cldn14 |
| Inheritance Mode | Recessive | Transmission | Germline |
| Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | A 3' portion of exon 3 was replaced with lacZ and neo, both simaltaneously inserted via homologous recombination of a targeting vector. The expression pattern of lacZ recapitulated that of the endogenous gene. Transcript was undetected by RT-PCR analysis of mRNA obtained from homozygous mutant kidneys. Immunostaining showed an absence of protein in sensory hair cells of homozygous mutant mice. |
