| First Author | Liljedahl M | Year | 1998 |
| Journal | Immunity | Volume | 8 |
| Issue | 2 | Pages | 233-43 |
| PubMed ID | 9492004 | Mgi Jnum | J:85084 |
| Mgi Id | MGI:2671681 | Doi | 10.1016/s1074-7613(00)80475-6 |
| Citation | Liljedahl M, et al. (1998) Altered antigen presentation in mice lacking H2-O. Immunity 8(2):233-43 |
| abstractText | HLA-DM catalyzes the release of MHC class II-associated invariant chain-derived peptides (CLIP) from class II molecules. Recent evidence has suggested that HLA-DO is a negative regulator of HLA-DM in B cells, but the physiological function of HLA-DO remains unclear. Analysis of antigen presentation by B cells from mice lacking H2-O (the mouse equivalent of HLA-DO), together with biochemical analysis using purified HLA-DO and HLA-DM molecules, suggests that HLA-DO/H2-O influences the peptide loading of class II molecules by limiting the pH range in which HLA-DM is active. This effect may serve to decrease the presentation of antigens internalized by fluid-phase endocytosis, thus concentrating the B cell-mediated antigen presentation to antigens internalized by membrane immunoglobulin. |
