| First Author | Qi L | Year | 2001 |
| Journal | J Immunol | Volume | 167 |
| Issue | 3 | Pages | 1371-8 |
| PubMed ID | 11466355 | Mgi Jnum | J:120491 |
| Mgi Id | MGI:3706643 | Doi | 10.4049/jimmunol.167.3.1371 |
| Citation | Qi L, et al. (2001) H2-O inhibits presentation of bacterial superantigens, but not endogenous self antigens. J Immunol 167(3):1371-8 |
| abstractText | H2-O/HLA-DO are MHC class II accessory molecules that modulate exogenous Ag presentation. Most class II accessory molecules are expressed in all professional APC; however, H2-O is only expressed in B cells and medullary thymic epithelial cells. Because B cells present exogenous Ags and superantigens (SAgs), and medullary thymic epithelial cells are specialized APC for self Ags during negative selection in the thymus, we have hypothesized that H2-O might play a role in MHC class II-restricted SAg and self Ag presentation. In this study, we demonstrate that H2-O expression inhibits presentation of the bacterial SAgs staphylococcal enterotoxins A and B to four SAg-reactive T hybridoma cells. In contrast, H2-O has no effect on presentation of endogenous self Ags, as measured by tumorigenicity in vivo and Ag presentation to three self Ag-specific T hybridoma cells. Additional experiments suggest that H2-O inhibits presentation of exogenous Ags by both newly synthesized and recycling MHC class II molecules. These data suggest H2-O may have a physiological role in tolerance induction and SAg-mediated toxic shock. |
