| Primary Identifier | MGI:2675597 | Allele Type | Spontaneous |
| Gene | chtl | Inheritance Mode | Recessive |
| Strain of Origin | B6.129P2-Nos2<tm1Lau>/J | Is Recombinase | false |
| Is Wild Type | false |
| description | A test for allelism with homozygous cht mouse mated to a homozygous mutant mouse produced 32/32 progeny with a dull grey phenotype, unlike cht or a/a . These results suggested chtl is a new allele of the cht gene that produces a different phenotype from the original cht allele. When two matings of the grey color F1s from the allele test progeny were mated together, however, they produced segregating litters for a total of 10 cht looking mice and 3 normal black a/a mice. The appearance of the black mice means either the two mutations are pseudoalleles or modiefier genes can affect the phenotype expresssion. |
| molecularNote | The chocolate-like spontaneous mutation was found at The Jackson Laboratory in 1998. A test for allelism to the cht locus demonstrated that the two mutations are in pseudoalleles or that modifier genes in the two background strains can affect the phenotype expression. |
